Monday, January 31, 2011

Lipids and Heart Heath

I consider fasting monthly is a very healthy exercize. I have noticed that I also have very oily skin at times. The key to lowering triglycerides is reducing sucrose and fructose. Fresh fruit is okay because the vitamins and fiber is worth it, whole grain starchy carbs is okay as starch is made from glucose and hopefully you get some more fiber. Otherwise I think eating 3 meals with 3 healthy snacks in-between to be key. Skipping meals and starving your body and then eating one large meal at the end of the day can be harmful long term. I will try to explain.

The decrease in oily skin you experience is not so much a function of not eating anything, but not eating refined sugars (sucrose, high fructose syrup). The liver turns fructose directly into triglycerides. Therefore, eating fructose is like eating fat. Fructose also inhibits insulin and leptin (full signal). Consequently, we see the correlation and association with high fructose diet and metabolic syndrome in the US (obesity, diabetes, coronary artery disease (CAD)).

As far as HDL and LDL goes, we know that rabbits with bad LDL receptors and high blood LDL levels (familial hypercholesterolemia) get CAD. However, the bad actor is not the LDL itself, but oxidized LDL. The reason LDL gets oxidized is because people with bad LDL receptors take a long time to transport the LDL into their cells. And, the longer the LDL is hanging out in the blood stream, the more likely chance it has to get oxidized. ox-LDL then doesn't get transported out of the blood stream well, and is responsible for the endothelial plaque formation on artery walls.

But our family problem is not LDL, but VLDL. Our family doesn't have the LDL hypercholesterolemia, but the high VLDL (triglycerides) and low HDL. Traditional Medicines goal is to reduce LDL and triglyceride (TG) levels and raise HDL. However, I have seen data that shows that low LDL is associated with Alzheimer's. So, I think that the goal should be to prevent LDL oxidation.

Traditional Medicine:
Statins: block HMGcoA Reductase blocks Cholesterol synthesis by the liver.
Niacin: blocks VLDL production, slows HDL removal from blood stream
Fish Oil: can raise LDL, HDL, and lower Triglycerides (TGs)
Vytorin: decrease cholesterol absorption
Bile Acid Binders: binds cholesterol and choline, choline is needed for VLDL export from liver.
Psillium Fiber: slows absorption of TGs from gut.
Vitamin E: antioxidant of LDL, decreases HDL size
Co-Enzyme Q10: antioxidant of LDL

My view (The Bad):
Statins: It doesn't make sense to inhibit Cholesterol. Cholesterol is needed to make Cortisol, Vitamin D, and Testosterone, so inhibiting it makes a man sick, senile, stressed, and sterile (4 S's).
Vytorin: same as above, the liver makes 40 times the cholesterol then you get from your diet.Cholesterol is good not bad.
Bile Acid Binders: It doesn't make sense to bind up Bile acids because you then lose cholesterol and choline. Low Cholesterol = 4 S's and Low Choline = fatty liver, and Gallstones. The liver will still make VLDL, but it needs Choline to transport VLDL out of the liver.
Flouride: It is my suspicion that Fluoride is as bad for the body as Mercury, Lead and Arsenic. Sure it may help teeth, but at what cost. It is my suspicion that the very reactive Fluoride causes chronic damage and calcifications in the brain and blood vessels. I am thinking about switching to peroxide and baking soda to brush my teeth or a non-fluoride toothpaste.

My View (The Good):
Diet: Eating small frequent meals makes sense to prevent high Triglyceride levels and overwhelm deficient VLDL receptors.
Exercise: Always a good thing. "Move it or lose it."
Decreased Processed Sugar: Cutting down on refined fructose and sucrose will naturally lower Triglyceride levels because the liver converts fructose to triglyceride
Psillium Fiber: Increasing fiber in the diet will slow the absorption of TGs..Fiber binds up TGs in the gut.
Lard and Butter(Saturated Fat): I think we should go back to using natural products and avoid artificial Crisco and Margarines. Saturated Fat actually directly raises HDL. HDL is high density because saturated Fats can pack together tightly.

My View (Uncertain but doubtful):
Fish Oil: don't know, but i have tried it and it didn't raise my HDL. Fish oil has lots of polyunsaturated fats which don't pack well and therefore are carried by LDL. Thus we see that people who take Fish Oil have higher LDL. The reason why HDL may go up is only due to the fact that Fish Oil tabs are 25% Saturated Fat.
Niacin: don't know, but i have tried it and it didn't raise my HDL.Niacin is believed to deceases TG and VLDL formation in the Liver and decreased mobilization of TGs from fat cells. While the result of supplementation may be a better looking lipid profile, I think its better to decrease processed Fructose/Sucrose consumption then interfere with the livers job of getting rid of it.

My View (Uncertain but promising):
Vitamin E: Needs vitamin C. makes sense to prevent oxidation of LDL but studies show mixed results that it also decreases HDL size which is bad. But these studies may have included people who were eating low saturated fat diets. Low saturated Fat = decreased HDL = decreased Vit E carrying capacity = no effect.
Co Enzyme Q10: Prevents LDL oxidation. This shows promise as Ubiquinone is a very important lipid soluble antioxidant in the body.

1 comment:

Anonymous said...

Niacin comes in several forms. Some work, some don't. Immediate-release forms (i.e. plain niacin) raises HDL significantly at doses from 3 to 5 grams a day. Extended-release forms of niaicn raise HDL slightly less but lower LDL and triglycerides a bit more.

Non-flush types of niacin don't work. For example, Inositol hexanicotinate releases niacin in the blood, but the level is a thousand times less than an equivalent amount of plain niacin.

The niacin flush is caused in part by the release of prostaglandins and can be lessened by aspirin. However, some of the flushing is caused by the release of serotonin from platelets. This is why aspirin does not eliminate flushing.

Saturated fat can increase HDL more so than niacin, provided refined carbohydrate consumption is minimized.