Sunday, July 20, 2014

Sulfate and Chronic Disease

Inorganic Sulfate is one of the most abundant anions in human and mammalian plasma. Sulfate plays an important physiological role in detoxifying xenobiotics, activating steroids, cholesterol, vitamin D, neurotransmitters, and bile acids. Sulfate is needed for the biosynthesis of glycosaminoglycans, cerebroside sulfate, and heparin sulfate.  Sulfate conjugation is a major liver pathway necessary for detoxifying and excreting toxins in the body and bloodsteam.  In mammals, sulfate homeostasis is regulated by the kidney. The majority of filtered sulfate is reabsorbed in the proximal tubules, and only 5–20% of the filtrate is excreted into the urine.

A few recent scientific papers are making a possible connection between serum sulfate levels and several chronic diseases including: osteoarthritis, preeclampsia, dementia, inflammatory bowel disease, peptic ulcer disease, hypertension, type 2 diabetes, DIC, asthma, eczema, lupus, chronic fatigue, wrestless legs, multiple sclerosis, autism, heart disease and cancer. How could all these different conditions be related? Well, the thinking is that all these chronic diseases are related to serum sulfate deficiency, and the specific disease process depends on where in the body sulfate is being scavenged/cannabilized from. 

Interesting point here is that sulfate-containing medicines are already used in many of these disease processes. Magnesium sulfate is already used in preeclampsia, hypertension, and asthma. Vitamin D has been shown to improve symptoms in autism, multiple sclerosis, dementia, inflammatory bowel and numerous other autoimmune conditions. Chondroiton sulfate is used in osteoarthritis, and heparin sulfate is used in DIC.

What is the connection between vitamin D and sulfate?  Turns out sun exposure not only activates vitamin-D but also is required to produce cholesterol sulfate and vitamin-D sulfate. Cholesterol sulfate is then incorporated into cell walls and endoplasmic reticulum to increase cell wall plasticity, protect from oxidative damage, facilitate transmembrane glucose transport, and protein post-translation modifications. 

Tragically, despite its importance, sulfate metabolism is not discussed much if at all in modern medical education.  Also, serum and urinary sulfate levels are not routinely measured in the hospital or clinical settings. In fact in all my medical career, I have never seen or heard of a serum or urinary sulfate level being checked.  Sulfate concentration is easily measured using a barium assay.

Furthermore. there are several factors that can lead to deficiencies in sulfate levels.  1. Penicillin antibiotics kill nitrate-metabolizing bacteria in the gut but not sulfate-metabolizing bacteria. Sulfate-metabolizing bacteria overgrow and reduce whole-body sulfate levels. 2. Aluminum (Alum) containing adjuvant vaccines can lead to deficiencies in serum sulfate, vitamin D sulfate, and cholesterol sulfate.  3. Consumption of Alum-containing foods such as pickles, iodized salt, and baking powder can exacerbate these disease states.  4. Fasting followed by the consumption of a carbohydrate-only meal can lead to a significant 50% drop in serum sulfate levels. 5. Statins inhibit cholesterol syntheses in the liver and brain. 6. Oil-in-water squalene vaccines can result in anti-cholesterol and anti-vitamin D antibodies.  7. The increased clearance of vitamin D and cholesterol by the immune system because of either Alum or squalene adjuvants can lead to decreased total body serum sulfate levels. 8. Tylenol (acetaminophen) ingestion causes decreased sulfate levels due to liver detoxification via sulfate conjugation (phase 2) and consumption of the sulfur-containing glutathione antioxidant.

The key to treating many of these disease states may be simply to supplement the diet with magnesium sulfate or Epsom salt and vitamin D3.  Epsom salt is safe to consume orally except in those with kidney failure. Ingesting too much MgSO4 will be eliminated by the kidney or not absorbed at all, resulting in diarrhea. Like sodium, potassium, and calcium, it is important not to take more magnesium than the body needs and can excrete.  Despite what advertisements claim, sulfate is not absorbed in any significant way by adding MgSO4 to the bath water. The only benefit of an Epsom salt bath is that you can stay in longer without getting pruney.

A safe daily dose of Epsom salt is about 1/2 tsp MgSO4 in 8 oz. fluid.  This works out to be about 2.5 gm MgSO4.7H2O or 250 mg elemental magnesium (10%).  In addition to supplemental sulfate, 5000-10,000 units of vitamin D daily is also recommended.  For comparison, 10 minutes of sun expose produces 10,000 units of Vitamin D. However, in addition to vitamin D supplementation, getting at least 10 minutes of sun exposure daily is necessary to produce cholesterol sulfate.  

*****1 tsp MgSO4.7H2O (magnesium sulfate heptahydrate) = approx. 5 gm/tsp = 10% elemental Mg = 500 mg per tsp.
*****RDA of Magnesium is about 400 mg daily.

As far as cholesterol itself goes, the liver already makes 1-2 gm daily which is much more cholesterol than you could ever ingest by eating eggs (300-500 mg).  However, eating eggs is still important because the lecithin in egg yoke is required for efficient transport of cholesterol out of the liver. 

You might wonder why you can't just get enough sulfate in your diet without supplementing. The answer is because most food is grown using inorganic fertillizer which, except for Austrailia, does not include sulfur.  Even organically grown food can be sulfur deficient because the chickens and cattle that produce the manure are fed a sulfate poor feed (soy and corn) and consequently produce a sulfate-poor manure.

I believe God did not create the human body to have the myriad of chronic health problems we are now seeing. Even among those who try and eat healthy and exercise regularly are seeing an explosion of chronic disease. The way I see it, either God designed a flawed human body or we are ingesting something harmful (nitrites) and/or missing something essential in our diets (sulfates).

According to the Institute of Medicine, Food and Nutrition Board 2004 "Dietary Reference Intakes: Water, Potassium, Sodium, Chloride, and Sulfate", they give no recommended daily intake of sulfate. They list a long but still incomplete table of sulfate-containing biochemicals in the body.  However, their conclusion is that recycled sulfate from protein and dietary protein is probably enough. They also say sulfate is an industrial pollutant, tastes bad in well water, and could give you diarrhea. Also, they say supplemental sulfate could lead to ulcerative colitis. This assertion is based on a study finding of sulfur-metabolizing bacteria in the gut of patients with UC. (this dismissive attitude against sulfate makes me a little suspicious)

But as I point out above, the sulfur-metabolizing bacteria actually lower overall sulfate levels which is more likely the cause of UC and not the presence of the bacteria and the resultant hydrogen sulfide gas itself. For one thing, treatments targeting the bacteria do not cure the disease.  Correlation does not equal causation.

My argument in advocating for sulfate supplementation is precisely for the reason stated in the Institute of Medicine guidelines paper.  They say you don't need sulfate because you can simply cannabilize it from protein and other molecules.  This cannabilization I believe is precisely the cause of many of the chronic diseases we are seeing today.

FYI: I do not generally advocate vitamin or mineral supplementing.  I think in most cases, taking excess vitamins and minerals can cause more harm than good and studies have not shown benefit but increased harm (manganese, vitamin E, etc).

In mice lacking the vitamin D receptor (VDR), NaSi-1 expression in the kidney was reduced by 72% but intestinal NaSi-1 levels remained unchanged. In connection with these findings, urinary sulfate excretion was increased by 42% whereas serum sulfate concentration was reduced by 50% in VDR knockout mice. Moreover, levels of hepatic glutathione and skeletal sulfated proteoglycans were also reduced by 18 and 45%, respectively. (Yan et al., Critical role of vitamin D in sulfate homeostasis, 2004)

According to the national guidelines, the body metabolizes up to about 3 - 6 gm inorganic-source and organic-source sulfate daily. According to the article, at least 1.5 - 3 gm comes from inorganic-source sulfate in food and water and 1.5 -3 gm organic-source sulphate comes from digestion and breakdown of sulfur-amino-acids. However, they make a point that total dietary sulfate can be much less than 1.5 gm.  Soy and corn are poor quality protein sources precisely because of their low sulfur-amino-acid content.

MgSO4.7H2O -- Mg: 24, SO4: 32 + 16 x 4 = 98, 7H2O: 16 + 2 = 18 x 7 = 126
Total mass per mole = 248
% Mg = 24/248 = 10%
% SO4 = 98/248 = 40%

Interesting that 1/2 the mass of MgSO4 is water and there can be variation in how much 1 tsp weighs depending on humidity and storage from 4.5 gm/tsp to 6.5 gm/tsp.   But anyways, assuming about 1 tsp = 5 gm, then SO4 would be about 2 gm SO4. 1/4 tsp would be 500 mg SO4.

A study of Vets measuring serum sodium measured got a range of 0.2 mM to 0.5 mM.  It would be really super hard to predict an increase in serum levels by 500mg or 2 gm oral Sulfate because of considering absorption (80%), and elimination and whole body distribution. Like other electrolytes like Mg and K etc, the serum levels are only a tiny fraction of the whole body stores.  But I think that it is good when you are thinking about taking a supplement that you are within the ballpark. (considering normal kidney function).

Sunday, June 08, 2014

No Economic Collapse

President Smith said that the conditions after the war would be "dreadful"

38 For as in the days that were before the flood they were eating and drinking, marrying and giving in marriage, until the day that Noe entered into the ark, (New Testament, Matthew, Matthew 24)

Yes, the FED is printing money and getting the US in debt that we can never repay. There is no way out of the hole we are digging. That said, there will be no collapse before war. The FED can continue to print money and bail Europe out until war comes. The threat of economic collapse is providing cover for the elite to prepare for nuclear WW3. However, when the elite come out of their bunkers, they will claim that Russia and China deceived them and that they had no idea Russia and China were expanding and modernizing their nuclear capability while the US has been unilaterally disarming.

After the attack on the West by Russia and China, the scheme is to trick the US into giving up our sovereignty to NATO to prosecute this war against the great communist threat.  Thus we walk right into the globalist hands.  The UN and their global warming/carbon tax is another bogie man which is meant to distract us from giving up sovereignty to NATO.

The FED will still print and bail out the world until Russia China deal the decapitating nuclear first-strike on the US. They know Obama is weak and carries the nuclear football and would stand down after a first-stike. US missiles are off "Launch on warning". Russia and China will likely not pass up on the opportunity to strike a weak president.

The threat of economic collapse is real but a cover. The FED knows they can keep this bailout game going until war (WW3) when they will just walk away from their debt, do a global reset and start over.

That said, before WW3, the globalist still need to confiscate weapons in the US. Russia and China can't effectively invade the US and martial law cannot effectively be maintained if everyone is armed.  So, there still needs to be some orchestrated event to motivate an attack on the second amendment. The random school shootings we have seen thus far were enough to rid guns from Europe but not the US.  Some have postulated that a limited collapse of the EBT system would generate instant riots and the sort if violence that could lead to gun confiscation. (this has been tested).  I just can't imagine what civilian force the President Obama referred to that would do the door-to-door confiscations.  We have seen these operations tested following Hurricane Katrina and the Boston Bombings.

Obama-Care increases ER visits

Drudge Report links to an articke reporting that Obama-Care has increased ER visits in Kentucky by 12 percent.  Most of these visits are nonemergent. This is likely to continue to increase. Despite what the article says this should be no surprise.  ER visits in Europe and Massachusetts increased by a similar 15 percent after implementing socialized health care.  Those in the business knew this all along.  Common sense says that If people have a benifit, they will use it.  But additionally, many private  physicians are refusing to accept Obama-care while the few that do are too busy to see the deluge of new patients.  Finally, there are no barriers (e.g. expensive co-pay) other than long wait times to being seen in the ER.  The ER has always been the US universal healthcare system. The ER has always seen anyone and everyone without appointment and regardless of insurance status.

Monday, June 02, 2014

Soviet Archives

Joel Skousen reports on Dr. Stanley Monteith's "Radio Liberty" about several collections of communist communications smuggled out of Russia soon after the false fall of the Soviet Union.  These documents reinforce that the spontaneous collapse of the Soviet Union was an illusion.  The same people are in charge and allied communists were active in Europe in encouraging European countries to join the Socialist European Union.  Skousen comments on a report by Claire Berlinski that western media has been complicit in a coverup.  It is Skousen's opinion that Russia maintains control of its former Eastern Bloc possessions and has continued to modernize and expand its military capability in preparation for a surprise nuclear attack in the West. 

http://www.city-journal.org/2010/20_2_soviet-archives.html

http://www.bukovsky-archives.net/pdfs/perestr/perestr-r.html

The problem is that most of these archives are not translated into English. There is as yet no "smoking gun" document that proves Skousen's assertions. It may be that these documents are just more controlled opposition like WikiLeaks and Eric Snowden.  If these archives contained anything damaging, Im sure people would turn up suicided or arrested like Aaron Swartz of Anonymous and Lulzsec.

Thursday, April 24, 2014

Patriotism and Family

A recent news story reported on an increasing trend of young single and even married American women foregoing childbearing and adopting dogs instead.  I actually have several co-workers who fit this trend and who routinly show off pictures of their canine "baby" (marriage and sterility problems notwithstanding).

In other news we hear about the increasing hostilities between the Ukraine and Russia.  In addition to politics, and control of natural resources, one of the major issues at play is that not enough Ukrainians live in Eastern Ukraine.  Instead, Eastern Ukraine is populated by numerous ethnic Russians and Russian speakers.   The Russian population in Ukraine is providing an excuse for Russia to encroach on sovereign Ukrainian territory.  Russia claims a responsibility to protect Russians from the political and social instability in Ukraine even if much of the instability is secretly caused by Russia.

What does Ukrainian politics and dogs have to do with one another?  The root problem in Ukraine or any territorial dispute is that possession is 9/10th of the law.  Because of decreased fertility rates and increasing immigration, Ukraine has been slowly losing its territory.  The same trends of decreased fertility and invreased illegal immigration is occuring in America and Europe.

I think people in ancient times had a much clearer view on this issue that we do today.  We talk about patriotism and preserving fredoom by being in the military and risking life or even taking life. I think the most valuable way to preserve feedom and defend the Constitution is not necessarily by taking life but instead by giving life.  If we believe Christian America is a superior way to live, then why not raise a family instilling in our children Christian values, understanding, and appreciation for our God-given Constitutional freedoms?

If you love America then why not bare and raise Christian-American offspring?  My Puerto Rican co-workers say that Peurto Rico doesn't seem to have the same problem America does.  They joke that Puerto Ricans are net exportors of Puerto Ricans.  There are more Puerto Ricans that live outside Puerto Rico than live on the small Island. If trends continue as they are, it might not take many more generations before the US begins loosing its claim on the territory that our forefathers shed their blood to obtain and secure.