Sunday, December 06, 2020

Pathogenic Priming


In SARS, a type of “priming” of the immune system was observed during animal studies of SARS spike protein-based vaccines leading to increased morbidity and mortality in vaccinated animals who were subsequently exposed to wild SARS virus. The problem, highlighted in two studies, became obvious following post-vaccination challenge with the SARS virus [2]. found that recombinant SARS spike-protein-based vaccines not only failed to provide protection from SARS-CoV infection, but also that the mice experienced increased immunopathology with eosinophilic infiltrates in their lungs. Similarly [3], found that ferrets previously vaccinated against SARS-CoV also developed a strong inflammatory response in liver tissue (hepatitis). Both studies suspected a “cellular immune response”.

structural characterization of the fusion core in syncytin envelope protein of human endogenous retrovirus family W.  Rui Gong et al. Biochem Biophys Res Commun. 2005.



The vaccine being taken forward, BNT162b2, encodes an optimized version of the whole spike protein, which should lead to “more consistent responses across diverse populations and in older adults,”


Friday, April 17, 2020

Origin of SARS-CoV-2

1. What is not debated is that both the US, Canada, and China were all working on SARS/Coronavirus "gain-of-function" research.  

"In October 2014, the US government imposed a moratorium on federal funding of such research on the viruses that cause SARS, influenza and MERS (Middle East respiratory syndrome, a deadly disease caused by a virus that sporadically jumps from camels to people).

The latest study was already under way before the US moratorium began, and the US National Institutes of Health (NIH) allowed it to proceed while it was under review by the agency, says Ralph Baric, an infectious-disease researcher at the University of North Carolina at Chapel Hill, a co-author of the study. The NIH eventually concluded that the work was not so risky as to fall under the moratorium, he says." (https://www.nature.com/news/engineered-bat-virus-stirs-debate-over-risky-research-1.18787)

2. this SARS-CoV-2 shows telltale signs of genetic engineering 

3. Canada and the US sent millions in  funding to the Wuhan lab. 
https://www.foxnews.com/politics/u-s-canada-have-funded-chinese-lab

4. SARS-CoV-2 could have been accidently released by the Wuhan lab.  It is not likely that COVID-19 would have been purposefully released by either the China or the US.  However, it is possible that an engineered virus could have been planted by a globalist 3rd party, getting both sides to point fingers at one another in order to foment tensions (which is what is happening). If it was just an accident, then why the hostility? 

5. I'm especially interested in the links between the SARS-CoV-2 and HIV.  The circulating virus binds to a second receptor on T-lymphocytes shows a higher level of sophistication and engineering than even the UNC or Wuhan lab were known to be working on 

6. We have an American who worked at the Wuhan lab and attests to their employment of full Level 4 containment precautions.  The media had been making the Wuhan lab sound more like a midevil alchemy lab than a modern virology with international level 4 containment precautions. Some people would consider that a reliable source where others point to a potential conflict of interest.  What would be a better, more reliable source? Is FOX is telling us how to think?

7. There is a brief chinese article I read talking about a worker at the Wuhan lab who worked with bats and coronavirus and self-quantijed himself several times worried about possibly having accidently contaminated himself.

8.  The key here is that Patient Zero, looks like he was a worker at the Wuhan lab. But it seems clear this person had no idea he was infected and traveled around the countryside unknowingly spreading the virus. 

It seems to me, if there was an accidental exposure (usually a needle stick through a glove), the  worker would have suspected it and self-quarantined as opposed to living life as usual. 

9. If I were a 3rd Party, trying to foment hostilities between China and US, this is exactly how I would have conducted a false-flag operation. 

10.  This situation sounds a lot like Goldfarb writing about the Polonium poisoning of Alexander Litvinenko. Goldfarb documented evidence of KGB agents spreading traces of polonium all over their hotel room, something a person would only do if they didn't know they had been contaminated with it by a 3rd party. interesting that  Goldfarb himself worked for George Soros, and had an extensive background working in nuclear chemistry.  Goldfarb himself,  in my opinion, was the source of the polonium and Litvinenkos killer. 



Thursday, February 27, 2020

Coronavirus/COVID-19 ARDS Protocol

As you know, most people who contract coronavirus/COVID-19 experience a flu-like illness. A percentage of suffered will develop pneumonia and a percentage of those will develop ARDS/ALI. ARDS has about a 50% mortality which would be expected to increase in a pandemic situation where resources become scarce.

The sample’s overall case-fatality rate was 2.3%, higher than World Health Organization official 0.7% rate. No deaths occurred in those aged 9 years and younger, but cases in those aged 70 to 79 years had an 8% fatality rate and those aged 80 years and older had a fatality rate of 14.8%.

ARDS is not well understood, but the leading understanding is acute lung injury is caused by a combination of pro- inflammatory cytokine cascade, high FIO2 exposure, and barotrauma.

Leading experimental measures which may amiliorate ARDS and maximize survival:

1. Limit high FIO2 exposure, increase PEEP
2. Low tidal volumes and increased frequency.
3.Program vent with regular (10/hr) sigh breaths (2xVT) to aid recruitment. 
3. Early tracheostomy.
4. Sedation with Precedex (dexmedetomidine).
5.Taurine infusion or NAC (antioxidant)
6. Treatment with ARB (angiotensin 2 blocker).  Coronavirus binds to and enters cells via AT2 receptor and early studies with SARS/MERS/CoVID-19 show benefit with ARBs.  
7. Kaletra effective for SARS/MERS/CoVID-19
8. Actemra, IL-6 

https://www.nature.com/articles/d41587-020-00003-1

ARBs in SARS/MERS/COVID-19
https://www.bmj.com/content/368/bmj.m406/rr-2

Vitamin C: 500mg as good as 2000mg
https://www.ncbi.nlm.nih.gov/m/pubmed/8317379/

Vitamin C Infusion didn't help ARDS/ALI
https://jamanetwork.com/journals/jama/article-abstract/2752063

Wednesday, February 19, 2020

Coronavirus Source

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797993/

"Experiments with the full length and chimeric SHC014 recombinant viruses were initiated and performed prior to the gain of function research funding pause and have since been reviewed and approved for continued study by NIH."

Level 3 lab at the University of North Carolina at Chapel Hill together with the Level 4 lab in Wuhan are responsible for creating a chimera/hybrid virus that showed increased human infectivity. This reasearch was funded by NIH and China. This virus was accidentally or not accidently released from Wuhan level 4 labs.  The level 4 designation is based on the Chinese lab's work with bioweapons but not based on precautions taken. The following paper demonstates examples of lax precautions and accidental contaminations at Wuhan lab.

https://www.scribd.com/document/447056518/Originsof2019-NCoV-XiaoB-Res

This coronavirus seems to target a race-specific Angiotensin 2 receptor polymorphism (+1166 C allele). 

https://www.nature.com/articles/hr2010156

https://www.nature.com/news/engineered-bat-virus-stirs-debate-over-risky-research-1.18787


Therapeutics
https://www.ncbi.nlm.nih.gov/m/pubmed/29557770/

https://www.medscape.com/answers/300455-107917/which-medications-are-used-for-the-treatment-of-coronavirus-pneumonia



https://www.biorxiv.org/content/10.1101/2020.01.24.915157v1.full.pdf
Co2019 is most similar to Bat-SARS-Co2015

https://www.nature.com/articles/nature12711

Interesting that coronavirus binds to the angiotensin 2 receptor.  AT2 is one of the most studied receptors in science. When I was in grad school, the lab next door did AT2 work (Dr. Terry S. Elton). The receptor has been fully sequenced, cloned, and is known to have several ethnic dna sequence polymorphisms. 

Also interesting that there is currently a global recall of ARBs or angiotensin receptor binding medications which have been shown to convey significant protection from the coronovirus. (Losartan, Telmisartan)

https://www.bmj.com/content/368/bmj.m406/rr-2




Vitamin C: 500mg as good as 2000mg
https://www.ncbi.nlm.nih.gov/m/pubmed/8317379/

Vitamin C Infusion didn't help ARDS/ALI
https://jamanetwork.com/journals/jama/article-abstract/2752063